Ex 26

Cat. No. 5833new

Ex 26 C28H28ClFN2O3 [1233332-37-0]

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Chemical Name: 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid

Biological Activity

Potent and selective S1P1 receptor antagonist (IC50 = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P1 over S1P2, S1P3, S1P4 and S1P5. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P1 receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.

Technical Data

M.Wt:
494.98
Formula:
C28H28ClFN2O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1233332-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Teijaro et al (2016) S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-a autoamplification. Proc.Natl.Acad.Sci.U.S.A. 113 1351. PMID: 26787880.

Cahalan et al (2013) Sphingosine 1-phosphate receptor 1 (S1P1) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P1 antagonist. Mol.Pharmacol. 83 316. PMID: 23204443.

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Keywords: Ex 26, supplier, Ex26, sphingosine-1-phosphate, S1P1, S1P1R, antagonists, antagonism, selective, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Antagonist products

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