Cat. No. 5830
Biological ActivityHigh affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
(Modifications: X=D-1-Nal,Trp-4 = D-Trp, Leu-6 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
M'Kadmi et al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021. PMID: 26363071.
Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437. PMID: 22920150.
If you know of a relevant reference for K-(D-1-Nal)-FwLL-NH2 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses K-(D-1-Nal)-FwLL-NH2 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: K-(D-1-Nal)-FwLL-NH2, supplier, ghrelin, receptors, inverse, agonists, agonism, peptide, potent, high, affinity, Tocris Bioscience, Ghrelin Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Negative control for ELA-32 (Cat.No.6291).ELA-32 (human)
Potent, high affinity apelin receptor agonist; stimulates angiogenesisParathyroid hormone (1-34) (bovine)
Parathyroid hormone (PTH) receptor agonist.Parathyroid hormone (1-34) (rat)
Parathyroid hormone (PTH) receptor agonistPeptide YY (3-36) human
NPY Y2 receptor agonistELA-14 negative control
Negative control for ELA-14 (Cat.No.6293).ELA-14 (human)
Potent apelin (APJ) receptor agonistRetrobradykinin
Reverse analog of BradykininTASP 0390325
Potent and selective V1B receptor antagonist; orally bioavailable
August 20 - 24, 2017
Paris , France