K-(D-1-Nal)-FwLL-NH2

Cat. No. 5830

K-(D-1-Nal)-FwLL-NH2 Lys-(D-1-Nal)-Phe-D-Trp-Leu-Leu-NH2

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Biological Activity

High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

Technical Data

M.Wt:
902.13
Formula:
C51H67N9O6
Sequence:
KXFWLL

(Modifications: X=D-1-Nal,Trp-4 = D-Trp, Leu-6 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1394288-22-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

M'Kadmi et al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021. PMID: 26363071.

Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437. PMID: 22920150.

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Keywords: K-(D-1-Nal)-FwLL-NH2, supplier, ghrelin, receptors, inverse, agonists, agonism, peptide, potent, high, affinity, Tocris Bioscience, Ghrelin Receptor Antagonist products

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