Hoechst 33258

Cat. No. 5824new

Hoechst 33258 C25H24N6O.3HCl [23491-45-4]

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Chemical Name: 4-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenol trihydrochloride

Biological Activity

Fluorescent dye. Binds the minor groove of DNA at A and T rich regions. Can be used as indicator of apoptosis.

Technical Data

M.Wt:
533.88
Formula:
C25H24N6O.3HCl
Solubility:
Soluble to 20 mM in DMSO and to 100 mM in water
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
23491-45-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Oberhammer et al (1993) Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12 3679. PMID: 8253089.

Jin and Breslauer (1988) Characterization of the minor groove environment in a drug-DNA complex: bisbenzimide bound to the poly[d(AT)].poly[d(AT)]duplex. Proc.Natl.Acad.Sci.U.S.A. 85 8939. PMID: 2461559 .

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Keywords: Hoechst 33258, supplier, DNA, minor, groove, binds, fluorescent, dyes, probes, Tocris Bioscience, Fluorescent Dye products

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