Bexarotene

Cat. No. 5819

Bexarotene C24H28O2 [153559-49-0]

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Alternative Name: LGD 1069

Chemical Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

Biological Activity

Potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

Technical Data

M.Wt:
348.48
Formula:
C24H28O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
153559-49-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Nie et al (2017) Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 18 624. PMID: 28099842.

Yen et al (2006) A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours. Br.J.Cancer 94 654. PMID: 16495926.

Boehm et al (1994) Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J.Med.Chem. 37 2930. PMID: 8071941.

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Keywords: Bexarotene, supplier, retinoid, X, receptors, agonists, agonism, RXR, α, β, γ, alpha, beta, gamma, potent, selective, cancer, metastasis, angiogenesis, LG1069, stem, cells, differentiation, brown, adipocytes, adipogenic, reprogramming, Tocris Bioscience, Retinoid X Receptor Agonist products

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