BSI 201

Cat. No. 5817

BSI 201 C7H5IN2O3 [160003-66-7]

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Alternative Name: Iniparib

Chemical Name: 4-Iodo-3-nitrobenzamide

Biological Activity

PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo.

Technical Data

M.Wt:
292.03
Formula:
C7H5IN2O3
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
160003-66-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ma et al (2012) Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc.Natl.Acad.Sci.U.S.A. 109 6590. PMID: 22493268.

Liu et al (2011) Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin.Cancer Res 18 510. PMID: 22128301.

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Citations are publications that use Tocris products.

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Keywords: BSI 201, supplier, BSI201, iniparib, PARP1, inhibitors, inhibits, poly(ADP-ribose), polymerase, cysteine-containing, proteins, modifiers, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products

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