Cat. No. 5817
Alternative Name: Iniparib
Chemical Name: 4-Iodo-3-nitrobenzamide
Biological ActivityPARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ma et al (2012) Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc.Natl.Acad.Sci.U.S.A. 109 6590. PMID: 22493268.
Liu et al (2011) Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin.Cancer Res 18 510. PMID: 22128301.
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Keywords: BSI 201, supplier, BSI201, iniparib, PARP1, inhibitors, inhibits, poly(ADP-ribose), polymerase, cysteine-containing, proteins, modifiers, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products
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