Cat. No. 5813
Chemical Name: N-[(1,1-dimethylethoxy)carbonyl]-L-
Biological ActivityWnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wang et al (2015) Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp.Cell Res. 331 115. PMID: 25445788.
Shan et al (2005) Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44 15495. PMID: 16300398.
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Keywords: NSC 668036, supplier, NSC668036, Wnt, signaling, inhibitors, inhibits, PDZ, domain, Dishevelled, Dvl, β, beta-catenin, Tocris Bioscience, Other Wnt Signaling Inhibitor products
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Wnt canonical signaling activator; also tubulin polymerization inhibitor
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