Cat. No. 5810
Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phen
Biological ActivityHigh affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548. PMID: 26817820.
Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848. PMID: 18840682.
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Citations are publications that use Tocris products.
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Keywords: RS 1, supplier, RS1, high, affinity, RAD51, activators, homologous, recombination, DNA, during, double, strand, break, repair, CRISPR, HDR, homology-directed, repair, Tocris Bioscience, DNA, RNA and Protein Synthesis products