RS 1

Cat. No. 5810

RS 1 C20H16Br2N2O3S [312756-74-4]

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Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide

Biological Activity

High affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548. PMID: 26817820.

Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848. PMID: 18840682.

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Keywords: RS 1, supplier, RS1, high, affinity, RAD51, activators, homologous, recombination, DNA, during, double, strand, break, repair, CRISPR, HDR, homology-directed, repair, Tocris Bioscience, DNA, RNA and Protein Synthesis products

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