RS 1

Cat. No. 5810

RS 1 C20H16Br2N2O3S [312756-74-4]

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Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide

Biological Activity

High affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.

Technical Data

M.Wt:
524.23
Formula:
C20H16Br2N2O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
312756-74-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548. PMID: 26817820.

Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848. PMID: 18840682.

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Keywords: RS 1, supplier, RS1, high, affinity, RAD51, activators, homologous, recombination, DNA, during, double, strand, break, repair, CRISPR, HDR, homology-directed, repair, Tocris Bioscience, DNA, RNA and Protein Synthesis products

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