SPL 334

Cat. No. 5809new

SPL 334 C22H15N3O3S2 [688347-51-5]

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Chemical Name: 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid

Biological Activity

S-Nitrosoglutathione reductase inhibitor. Prevents weight loss, and attenuates lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Luzina et al (2015) Pharmacological in vivo inhibition of S-nitrosoglutathione reductase attenuates bleomycin-induced inflammation and fibrosis. J.Pharmacol.Exp.Ther. 355 13. PMID: 26209236.

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Keywords: SPL 334, supplier, SPL334, S-nitrosoglutathione, reductase, inhibitors, inhibits, interstitial, lung, disease, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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