M 084 hydrochloride

Cat. No. 5807

M 084 hydrochloride C11H15N3.HCl

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Chemical Name: N-Butyl-1H-benzimidazol-2-amine hydrochloride

Biological Activity

TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.

Technical Data

M.Wt:
225.72
Formula:
C11H15N3.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136255. PMID: 26317356.

Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495. PMID: 25816897.

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Keywords: M 084 hydrochloride, supplier, M084, hydrochloride, TRPC4/5, blockers, inhibitors, inhibits, transient, receptor, potential, channels, canonical, TRPC, Tocris Bioscience, TRPC Blocker products

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