ISOX DUAL

Cat. No. 5806

ISOX DUAL C31H41N5O3

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Chemical Name: [3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl]phenoxy]propyl]dimethylamine

Biological Activity

Dual CBP/p300 and BRD4 bromodomain inhibitor (IC50 values are 0.65 and 1.5 μM for CBP and BRD4 respectively). Downregulates IL-6, IL-1β and IFN-β in macrophages.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
531.69
Formula:
C31H41N5O3
Solubility:
Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chekler (2015) Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 22 1588. PMID: 26670081.

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Keywords: ISOX DUAL, supplier, Dual, CBP/p300, BRD4, bromodomains, inhibitors, inflammation, macrophages, inhibits, Tocris Bioscience, Bromodomain Inhibitor products

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