Cat. No. 5806
Chemical Name: [3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-
Biological ActivityDual CBP/p300 and BRD4 bromodomain inhibitor (IC50 values are 0.65 and 1.5 μM for CBP and BRD4 respectively). Downregulates IL-6, IL-1β and IFN-β in macrophages.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chekler (2015) Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 22 1588. PMID: 26670081.
If you know of a relevant reference for ISOX DUAL please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ISOX DUAL from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: ISOX DUAL, supplier, Dual, CBP/p300, BRD4, bromodomains, inhibitors, inflammation, macrophages, inhibits, Tocris Bioscience, Bromodomain Inhibitor products
Find multiple products by catalog number
New Products in this Area
BET bromodomain inhibitor; orally bioavailableH3K4(Me2) (1-20)
Histone H3 peptideTC AC 28
High affinity BET bromodomain ligand
August 20 - 24, 2017
Paris , France