Chaetoglobosin A

Cat. No. 5804

Chaetoglobosin A C32H36N2O5 [50335-03-0]

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Chemical Name: (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione

Biological Activity

Antibiotic; preferentially induces apoptosis in chronic lymphocytic leukemia (CLL) cells over normal B cells. Inhibits actin polymerization and leads to the accumulation of cells in G2 phase.

Technical Data

M.Wt:
528.64
Formula:
C32H36N2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
50335-03-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Knudsen et al (2014) Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia 28 1289. PMID: 24280868.

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Keywords: Chaetoglobosin A, supplier, Antibiotics, induces, apoptosis, inducer, selective, chronic, lymphocytic, leukemia, CLL, actin, polymerisation, inhibitor, inhbits, Tocris Bioscience, Antibiotic products

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