MP A08

Cat. No. 5803

MP A08 C27H25N3O4S2 [219832-49-2]

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Alternative Name: NSC 122314

Chemical Name: 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide

Biological Activity

Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

Technical Data

M.Wt:
519.64
Formula:
C27H25N3O4S2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
219832-49-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pitman et al (2015) A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 6 7065. PMID: 25788259.

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Keywords: MP A08, supplier, MPA08, Selective, ATP, competitive, sphingosine, kinase, 1, and, 2, SphK, sk1, sk2, cell, permeable, anticancer, apoptosis, apoptotic, NSC122314, Tocris Bioscience, Sphingosine Kinase Inhibitor products

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