Cat. No. 5803
Alternative Name: NSC 122314
Chemical Name: 4-Methyl-N-[2-[[[2-[[(4-methylpheny
Biological ActivitySelective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Pitman et al (2015) A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 6 7065. PMID: 25788259.
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Keywords: MP A08, supplier, MPA08, Selective, ATP, competitive, sphingosine, kinase, 1, and, 2, SphK, sk1, sk2, cell, permeable, anticancer, apoptosis, apoptotic, NSC122314, Tocris Bioscience, Sphingosine Kinase Inhibitor products
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