Cat. No. 5802
Alternative Name: CM 037
Chemical Name: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrro
Biological ActivityALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Condello et al (2015) β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 34 2297. PMID: 24954508 .
Morgan and Hurley (2015) Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 58 1964. PMID: 25634381 .
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses A37 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: A37, supplier, Aldehyde, dehydrogenase-1A1, ALDH1A1, inhibitors, inhibits, CM037, Tocris Bioscience, Aldehyde Dehydrogenase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethalSPL 334
S-Nitrosoglutathione reductase inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.