Cat. No. 5802
Alternative Name: CM 037
Chemical Name: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrro
Biological ActivityALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Condello et al (2015) β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 34 2297. PMID: 24954508 .
Morgan and Hurley (2015) Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 58 1964. PMID: 25634381 .
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Keywords: A37, supplier, Aldehyde, dehydrogenase-1A1, ALDH1A1, inhibitors, inhibits, CM037, Tocris Bioscience, Aldehyde Dehydrogenase Inhibitor products