Mitoglitazone

Cat. No. 5799

Mitoglitazone C19H18N2O4S [146062-49-9]

Price and Availability

For Mitoglitazone pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: CAY 10415, MSDC 0160

Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Biological Activity

Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).

Technical Data

M.Wt:
370.42
Formula:
C19H18N2O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
146062-49-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Colca et al (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551. PMID: 23690925.

Divakaruni et al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422. PMID: 23513224.

Chen et al (2012) Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537. PMID: 22621923.

If you know of a relevant reference for Mitoglitazone please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Mitoglitazone from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Mitoglitazone, supplier, Antidiabetic, neurodegeneration, Alzheimer's, Parkinson's, diseases, mTOT, target, thiazolidinones, insulin, resistance, mitochondria, metabolism, pyruvate, carriers, MPC, hyperglycemia, Tocris Bioscience, Insulin and Insulin-like Receptor products

Quick Order

Find multiple products by catalog number

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Appetite Modulation

Written by S. Tucci et al

Peptides Involved in Appetite Modulation Scientific Review

Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis. View PDF today.

divider line

Angiogenesis in Cancer

Taken from the Cancer Guide Edition 3

Angiogenesis in Cancer Life Science Poster

Our Angiogenesis in Cancer poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets. Request copy or view PDF today.

divider line

Insulin Pathway

Insulin Signaling Pathway

Signals through the insulin pathway are fundamental for the regulation of intracellular glucose levels. View pathway or download PDF today.

divider line

New Products in this Area

CP 673451

Potent and selective PDGFR inhibitor

GSK 1363089

Potent inhibitor of MET, VEGFR2, Ron and AXL

PF 06273340

Potent and selective pan-Trk inhibitor; peripherally restricted

Sign-up for new product e-alerts
divider line

Bio-Techne Events

WCI 2017

13th World Congress on Inflammation

July 8 - 12, 2017

London, UK