Mitoglitazone

Cat. No. 5799

Mitoglitazone C19H18N2O4S [146062-49-9]

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Alternative Names: CAY 10415, MSDC 0160

Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Biological Activity

Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).

Technical Data

M.Wt:
370.42
Formula:
C19H18N2O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
146062-49-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Colca et al (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551. PMID: 23690925.

Divakaruni et al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422. PMID: 23513224.

Chen et al (2012) Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537. PMID: 22621923.

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Keywords: Mitoglitazone, supplier, Antidiabetic, neurodegeneration, Alzheimer's, Parkinson's, diseases, mTOT, target, thiazolidinones, insulin, resistance, mitochondria, metabolism, pyruvate, carriers, MPC, hyperglycemia, Tocris Bioscience, Insulin and Insulin-like Receptors products

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