Cat. No. 5795
Biological ActivityCXCR4 allosteric agonist (EC50 = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards Gi proteins over G13 and β-arrestin.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Planesas et al (2015) Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 60 1. PMID: 26080355.
Quoyer et al (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 110 E5088. PMID: 24309376.
Tchernychev et al (2010) Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 107 22255. PMID: 21139054.
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Keywords: ATI 2341, supplier, CXCR4, allosteric, agonists, polymorphonuclear, neutrophils, PMNs, hematopoietic, stem, progenitor, cells, HSPCs, biased, signaling, Tocris Bioscience, Chemokine CXC Receptor Agonist products
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