Bz 423

Cat. No. 5791

Bz 423 C27H21ClN2O2 [216691-95-1]

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Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one

Biological Activity

ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Blatt et al (2009) Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem.Pharmacol. 15 966. PMID: 19481066.

Johnson et al (2005) Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chem.Biol. 12 485. PMID: 15850986.

Blatt et al (2002) Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J.Clin.Invest. 110 1123. PMID: 12393848 .

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Keywords: Bz 423, supplier, Bz423, ATP, synthase, inhibitors, inhibits, pro-apoptotic, oligomycin, sensitivity, conferring, protein, OSCP, autoimmunity, superoxide, generation, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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