PF 05175157

Cat. No. 5790

PF 05175157 C23H27N5O2 [1301214-47-0]

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Chemical Name: 1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one

Biological Activity

Acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
405.49
Formula:
C23H27N5O2
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1301214-47-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Griffith et al (2014) Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. J.Med.Chem. 57 10512. PMID: 25423286.

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Keywords: PF 05175157, supplier, PF05175157, Acetyl, CoA, carboxylase, 1, 2, inhibitors, inhibits, ACC1, ACC2, orally, bioavailable, type, 2, diabetes, mellitus, Tocris Bioscience, Other Lipid Metabolism Inhibitor products

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