Cat. No. 5789
Chemical Name: (βS)-β-[4-[[4-Methyl-2-[4-(trifluorom
Biological ActivityPotent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Liu et al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517. PMID: 24900872 .
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses AM 4668 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: AM 4668, supplier, AM4668, free, fatty, acid, receptors, FFA1, FFAR, agonists, agonism, type, 2, diabetes, potent, orally, bioavailable, Tocris Bioscience, Free Fatty Acid Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
FFA2 antagonist/inverse agonistOleanolic acid
Selective GPBA receptor (TGR5) partial agonistPPTN hydrochloride
High affinity and selective P2Y14 antagonistItraconazole
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)SAR 216471 hydrochloride
Potent P2Y12 antagonist; orally availableA 971432
Potent and selective S1P5 agonistGLPG 0974
Potent FFA2 antagonistOgerin
Selective positive allosteric modulator at GPR68BGC 20-1531 hydrochloride
High affinity and selective EP4 antagonistMontelukast sodium
CysLT1 and GPR17 antagonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.