AM 4668

Cat. No. 5789new

AM 4668 C24H19F3O4S [1011531-27-3]

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Chemical Name: (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid

Biological Activity

Potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.

Technical Data

M.Wt:
488.48
Formula:
C24H19F3O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1011531-27-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Liu et al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517. PMID: 24900872 .

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Keywords: AM 4668, supplier, AM4668, free, fatty, acid, receptors, FFA1, FFAR, agonists, agonism, type, 2, diabetes, potent, orally, bioavailable, Tocris Bioscience, Free Fatty Acid Receptor Agonist products

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