MDNI-caged-L-glutamate

Cat. No. 5785new

MDNI-caged-L-glutamate C14H16N4O8 [864085-92-7]

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Alternative Names: caged MDNI glutamate, DNI glutamate, DNI-GLU

Chemical Name: (S)-α-Amino-2,3-dihydro-4-methoxy-5,7-dinitro-δ-oxo-1H-indole-1-pentanoic acid

Biological Activity

Rapidly and efficiently releases glutamate (Cat. No. 0218) when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate (Cat. No. 1490). Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.

Technical Data

M.Wt:
368.3
Formula:
C14H16N4O8
Solubility:
Soluble to 10 mM in water with gentle warming and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
864085-92-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Fedoryak et al (2005) Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells. Chem. Commun. (Camb.) 7 3664. PMID: 16027904.

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Keywords: MDNI-caged-L-glutamate, supplier, Stable, photoreleaser, L-glutamate, Caged, Compounds, Glutamate, mGlur, Receptors, Metabotropic, Non-Selective, iGlur, Ionotropic, agonists, MNI, glutamate, MNI-Glutamate, Tocris Bioscience, Miscellaneous Glutamate products

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