Cat. No. 5781
Chemical Name: N-5-Isoquinolinyl-N'-[[(4-(trifluoro
Biological ActivityPotent TRPV1 antagonist (IC50 = 3-9 nM). Blocks capsaicin-evoked currents in rat DRG neurons and inhibits TRPV1-activation by anandamide (Cat. No. 1339) and N-arachidonoyl-dopamine. Reduces pain in inflammatory, postoperative and osteoarthritic in vivo pain models.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
McGaraughty et al (2006) Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats. J.Neurophysiol. 95 18. PMID: 16162831.
El Kouhen et al (2005) A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid. J.Pharmacol.Exp.Ther. 314 400. PMID: 15837819.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses A 425619 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: A 425619, supplier, A425619, TRPV1, antagonists, antagonism, transient, receptor, potential, channels, vanilloids, pain, nociception, capsaicin, Tocris Bioscience, TRPV Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent TRPV1 antagonistPF 05105679
Selective TRPM8 blockerM 084 hydrochloride
TRPC4/5 channel blocker; antidepressant and anxiolytic
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.