Cat. No. 5774
Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-ind
Biological ActivityERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Herrero et al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170. PMID: 26267534.
Ryan et al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183. PMID: 26858988.
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Keywords: DEL 22379, supplier, ERK, dimerization, inhibitors, inhibits, extracellular, signal, related, kinase, RAS, Tocris Bioscience, ERK products
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