Cat. No. 5774
Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-ind
Biological ActivityERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Herrero et al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170. PMID: 26267534.
Ryan et al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183. PMID: 26858988.
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Keywords: DEL 22379, supplier, ERK, dimerization, inhibitors, inhibits, extracellular, signal, related, kinase, RAS, Tocris Bioscience, ERK products
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