DEL 22379

Cat. No. 5774

DEL 22379 C26H28N4O3 [181223-80-3]

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Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide

Biological Activity

ERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without effecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.

Technical Data

M.Wt:
444.53
Formula:
C26H28N4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
181223-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Herrero et al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170. PMID: 26267534.

Ryan et al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183. PMID: 26858988.

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Keywords: DEL 22379, supplier, ERK, dimerization, inhibitors, inhibits, extracellular, signal, related, kinase, RAS, Tocris Bioscience, ERK products

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