Cat. No. 5772
Alternative Name: AHU 377
Chemical Name: Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amin
Biological ActivityMembrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ksander et al (1995) Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 38 1689. PMID: 7752193.
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Keywords: Sacubitril calcium, supplier, AHU377, NEP, neprilysin, neutral, MME, membrane, metallo-endopeptidase, inhibitors, inhibits, prodrug, orally, bioavailable, natriuretic, natriuresis, ANF, Tocris Bioscience, Other Protease Inhibitor products
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