Sacubitril calcium

Cat. No. 5772

Sacubitril calcium C24H28NO5.½Ca [1369773-39-6]

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Alternative Name: AHU 377

Chemical Name: Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt

Biological Activity

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.

Technical Data

M.Wt:
430.52
Formula:
C24H28NO5.½Ca
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1369773-39-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ksander et al (1995) Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 38 1689. PMID: 7752193.

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Keywords: Sacubitril calcium, supplier, AHU377, NEP, neprilysin, neutral, MME, membrane, metallo-endopeptidase, inhibitors, inhibits, prodrug, orally, bioavailable, natriuretic, natriuresis, ANF, Tocris Bioscience, Other Protease Inhibitor products

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