Cat. No. 5770
Chemical Name: 2-[(4-Methoxy-2-naphthalenyl)amino]
Biological ActivityPotent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Boedtkjer et al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158. PMID: 26013995.
Oh et al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726. PMID: 23997117.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses MONNA from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MONNA, supplier, CaCC, TMEM16A, blockers, blocks, calcium-activated, chloride, channels, anoctamin-1, ANO1, potent, Tocris Bioscience, Calcium-activated Chloride Channel Blocker products
Find multiple products by catalog number
New Products in this Area
Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.