P-3FAX-Neu5Ac

Cat. No. 5760

P-3FAX-Neu5Ac C22H30FNO14 [117405-58-0]

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Chemical Name: 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate

Biological Activity

Cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.

Technical Data

M.Wt:
551.47
Formula:
C22H30FNO14
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
117405-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733. PMID: 25575241.

Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661. PMID: 22683610.

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Keywords: P-3FAX-Neu5Ac, supplier, sialic, acid, analog, sialyltransferases, inhibits, inhibitors, SLeX, Sialyl, Lewis, X, P-selectin, E-selectin, cell, adhesion, metastasis, Tocris Bioscience, Other Transferase Inhibitor products

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