SW 033291

Cat. No. 5759

SW 033291 C21H20N2OS3 [459147-39-8]

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Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine

Biological Activity

High affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.

Technical Data

M.Wt:
412.59
Formula:
C21H20N2OS3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
459147-39-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Zhang et al (2015) Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 345 aaa2340. PMID: 26068857.

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Keywords: SW 033291, supplier, SW033291, 15-PGDH, hydroxyprostaglandin, dehydrogenase, inhibitors, inhibits, hematopoiesis, hematopoietic, hepatocyte, proliferation, PGE2, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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