Cat. No. 5759
Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thi
Biological ActivityHigh affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zhang et al (2015) Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 345 aaa2340. PMID: 26068857.
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Keywords: SW 033291, supplier, SW033291, 15-PGDH, hydroxyprostaglandin, dehydrogenase, inhibitors, inhibits, hematopoiesis, hematopoietic, hepatocyte, proliferation, PGE2, Tocris Bioscience, Other Dehydrogenase Inhibitor products