AGN 193109

Cat. No. 5758new

AGN 193109 C28H24O2 [171746-21-7]

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Chemical Name: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid

Biological Activity

High affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits not significant affinity for retinoic X receptors.

Technical Data

M.Wt:
392.49
Formula:
C28H24O2
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
171746-21-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Nat.Commun. 6 7476. PMID: 26101153.

Levi et al (2015) Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5 Nat.Commun. 6 8794. PMID: 26592976.

Agarwal et al (1996) AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J.Biol.Chem. 271 12209. PMID: 8647816.

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Citations are publications that use Tocris products.

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Keywords: AGN 193109, supplier, AGN193109, high, affinity, selective, retinoic, acid, receptors, RAR, antagonists, antagonisms, Tocris Bioscience, Retinoic Acid Receptor Antagonist products

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