MLi-2

Cat. No. 5756new

MLi-2 C21H25N5O2 [1627091-47-7]

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Chemical Name: rel-3-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-pyrimidyl]-5-[(1-methylcyclopropyl)oxy]-1H-indazole

Biological Activity

Potent and selective LRRK2 inhibitor (IC50 = 0.76-3.4 nM depending on assay). Exhibits >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels. Centrally bioavailable and active in vivo.

Technical Data

M.Wt:
379.46
Formula:
C21H25N5O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1627091-47-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Fell et al (2015) MLi-2, a potent, selective, and centrally active compound for exploring the therapeutic potential and safety of LRRK2 kinase inhibition. J.Pharmacol.Exp.Ther. 355 397. PMID: 26407721.

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Keywords: MLi-2, supplier, leucine-rich, repeat, kinase, 2, LRRK2, inhibitors, inhibits, potent, neuroprotective, neuronal, injury, parkinson's, parkinsons, Tocris Bioscience, LRRK2 Inhibitor products

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