Cat. No. 5747new

Apcin C13H14Cl3N7O4 [300815-04-7]

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Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide

Biological Activity

Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Wang et al (2015) Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 151 141. PMID: 25850036.

Sackton et al (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 514 646. PMID: 25156254.

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Keywords: Apcin, supplier, Cdc20, inhibitors, inhibits, APC, anaphase-promoting, complex, ubiquitin, ubiquitination, ligases, E3, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products

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