Apcin

Cat. No. 5747

Apcin C13H14Cl3N7O4 [300815-04-7]

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Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide

Biological Activity

Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.

Technical Data

M.Wt:
438.65
Formula:
C13H14Cl3N7O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
300815-04-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wang et al (2015) Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 151 141. PMID: 25850036.

Sackton et al (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 514 646. PMID: 25156254.

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Keywords: Apcin, supplier, Cdc20, inhibitors, inhibits, APC, anaphase-promoting, complex, ubiquitin, ubiquitination, ligases, E3, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products

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