Cat. No. 5740

6-Hydroxy-DL-DOPA C9H11NO5 [21373-30-8]

Price and Availability

For 6-Hydroxy-DL-DOPA pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2,5-Dihydroxy-DL-tyrosine

Biological Activity

Allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

Technical Data

Soluble to 100 mM in 1M HCl
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491. PMID: 26548611.

Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621. PMID: 20809131.

Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740. PMID: 19484131.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses 6-Hydroxy-DL-DOPA from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: 6-Hydroxy-DL-DOPA, supplier, Allosteric, inhibitors, RAD52, APE1, BRCA, deficient, cancer, synthetic, lethality, inhibits, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area


PCNA inhibitor

Pladienolide B

mRNA splicing inhibitor; antitumor

Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.