Cat. No. 5740

6-Hydroxy-DL-DOPA C9H11NO5 [21373-30-8]

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Chemical Name: 2,5-Dihydroxy-DL-tyrosine

Biological Activity

Allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

Technical Data

Soluble to 100 mM in 1M HCl
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491. PMID: 26548611.

Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621. PMID: 20809131.

Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740. PMID: 19484131.

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Keywords: 6-Hydroxy-DL-DOPA, supplier, Allosteric, inhibitors, RAD52, APE1, BRCA, deficient, cancer, synthetic, lethality, inhibits, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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