Prostratin

Cat. No. 5739

Prostratin C22H30O6 [60857-08-1]

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Chemical Name: (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

Biological Activity

PKC activator. Inhibits growth and induces differentiation of AML cell lines. Enhances cytarabine-induced differentiation of AML cells. Inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Also NF-κB activator. Activates HIV gene expression in T cells. Orally available.

Technical Data

M.Wt:
390.47
Formula:
C22H30O6
Solubility:
Soluble to 75 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
60857-08-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Shen et al (2015) The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 356 686. PMID: 25449427.

Wang et al (2015) K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling. Cell 163 1237. PMID: 26590425.

Wang et al (2014) Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway. BioMed Res.Int. 2014 968027. PMID: 25136641.

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Keywords: Prostratin, supplier, protein, kinase, C, activators, PKC, activation, NF-KB, Kappa, κ, differentiation, AML, orally, available, HIV, signaling, Tocris Bioscience, Protein Kinase C Activator products

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