Cat. No. 5737
Chemical Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]ox
Biological ActivityMitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kenwood et al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858. PMID: 26119501.
Kenwood et al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114. PMID: 24634817.
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Keywords: BAM 15, supplier, BAM15, mitochondrial, uncouplers, oxidative, phosphorylation, respiration, protonophores, renal, ischemic-reperfusion, injury, Tocris Bioscience, Oxidative Phosphorylation products
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