BAM 15

Cat. No. 5737

BAM 15 C16H10F2N6O [210302-17-3]

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Chemical Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine

Biological Activity

Mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.

Technical Data

M.Wt:
340.29
Formula:
C16H10F2N6O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
210302-17-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kenwood et al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858. PMID: 26119501.

Kenwood et al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114. PMID: 24634817.

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Keywords: BAM 15, supplier, BAM15, mitochondrial, uncouplers, oxidative, phosphorylation, respiration, protonophores, renal, ischemic-reperfusion, injury, Tocris Bioscience, Oxidative Phosphorylation products

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