Cat. No. 5736
Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tet
Biological ActivityDNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Syväoja et al (1990) DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells. Proc.Natl.Acad.Sci.U.S.A. 87 6664. PMID: 1975694.
Spadari et al (1984) Control of DNA replication and cell proliferation in eukaryotes by aphidicolin. Toxicol.Pathol. 12 143. PMID: 11478315.
Bucknall et al (1973) Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob.Agents Chemother. 4 294. PMID: 4357181.
If you know of a relevant reference for Aphidicolin please let us know.
Citations are publications that use Tocris products.
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Keywords: Aphidicolin, supplier, DNA, polymerase, alpha, α, delta, δ, epsilon, ε, inhibitors, inhibits, antimitotic, antibiotic, antiviral, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products
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