Aphidicolin

Cat. No. 5736

Aphidicolin C20H34O4 [38966-21-1]

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Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol

Biological Activity

DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.

Technical Data

M.Wt:
338.48
Formula:
C20H34O4
Solubility:
Soluble to 25 mM in DMSO
Storage:
Store at -20°C
CAS No:
38966-21-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Syväoja et al (1990) DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells. Proc.Natl.Acad.Sci.U.S.A. 87 6664. PMID: 1975694.

Spadari et al (1984) Control of DNA replication and cell proliferation in eukaryotes by aphidicolin. Toxicol.Pathol. 12 143. PMID: 11478315.

Bucknall et al (1973) Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob.Agents Chemother. 4 294. PMID: 4357181.

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Citations are publications that use Tocris products.

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Keywords: Aphidicolin, supplier, DNA, polymerase, alpha, α, delta, δ, epsilon, ε, inhibitors, inhibits, antimitotic, antibiotic, antiviral, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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