S3QEL 2

Cat. No. 5735

S3QEL 2 C19H25N5 [890888-12-7]

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Chemical Name: 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Suppresses superoxide production by complex III in the mitochondria without affecting normal electron flux or cellular oxidative phosphorylation (IC50 = 1.7 μM). Suppresses HIF-1α accumulation and enhances survival and function of primary pancreatic islets in vitro. Cell permeable.

Technical Data

M.Wt:
323.44
Formula:
C19H25N5
Solubility:
Soluble to 20 mM in DMSO with gentle warming and to 20 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
890888-12-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Orr et al (2015) Suppressors of superoxide production from mitochondrial complex III. Nat.Chem.Biol. 11 834. PMID: 26368590.

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Citations are publications that use Tocris products.

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Keywords: S3QEL 2, supplier, S3QEL2, Suppresses, superoxide, production, complex, III, mitochondria, oxidative, phosphorylation, ROS, reactive, oxygen, species, inhibitors, inhibits, Tocris Bioscience, ROS and Other Gaseous Donor products

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