L-Dehydroascorbic acid

Cat. No. 5734

L-Dehydroascorbic acid C6H6O6 [490-83-5]

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Chemical Name: L-threo-2,3-Hexodiulosonic acid γ-lactone

Biological Activity

Oxidized form of L-Ascorbic acid (Cat. No. 4055). Transported into cells through GLUT1. Selectively induces cell death in KRAS and BRAF mutant cells in vitro.

Technical Data

Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kaiser (2015) Vitamin C could target some common cancers. Science 6 6261. PMID: 26542550.

Yun et al (2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science 11 6266. PMID: 26541605.

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Citations are publications that use Tocris products.

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Keywords: L-Dehydroascorbic acid, supplier, vitamin, vit, C, oxidised, form, L-Ascorbic, acid, GLUT1, glucose, transporters, KRAS, BRAF, Tocris Bioscience, Glucose Transporter products

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