Cat. No. 5734
Chemical Name: L-threo-2,3-Hexodiulosonic acid γ-lactone
Biological ActivityOxidized form of L-Ascorbic acid (Cat. No. 4055). Transported into cells through GLUT1. Selectively induces cell death in KRAS and BRAF mutant cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kaiser (2015) Vitamin C could target some common cancers. Science 6 6261. PMID: 26542550.
Yun et al (2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science 11 6266. PMID: 26541605.
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Keywords: L-Dehydroascorbic acid, supplier, vitamin, vit, C, oxidised, form, L-Ascorbic, acid, GLUT1, glucose, transporters, KRAS, BRAF, Tocris Bioscience, Glucose Transporter products