Cat. No. 5728
Chemical Name: 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol
Biological ActivityPotent and selective noncompetitive AT1 receptor antagonist (IC50 = 37 nM). Reduces blood pressure in a rat model. Active metabolite of losartan potassium (Cat.No. 3798).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 255 211. PMID: 2213556.
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Keywords: EXP 3174, supplier, EXP3194, losartan, carboxylic, acid, metabolite, hypertension, antihypertensive, AT1, antagonists, antagonism, angiotensin, II, potent, noncompetitive, selective, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products