MC 1742

Cat. No. 5727new

MC 1742 C21H21N3O3S [1776116-74-5]

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Chemical Name: 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide

Biological Activity

Potent class I and IIb HDAC inhibitor (IC50 values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 nM. Also induces osteogenesis in sarcoma CSCs at concentrations of 25 - 500 nM .

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Di Pompo et al (2015) Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J.Med.Chem. 58 4073. PMID: 25905694.

Mai et al (2008) Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. Bioorg.Med.Chem.Lett. 18 2530. PMID: 18381238.

Mai et al (2006) Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J.Med.Chem. 49 6046. PMID: 17004718.

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Keywords: MC 1742, supplier, MC1742, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, inhibitors, inhibits, histone, deacetylases, class, II, IIa, epigenetics, cancer, stem, cells, CSCs, osteogenic, differentiation, Tocris Bioscience, Histone Deacetylase Inhibitor products

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