Nilvadipine

Cat. No. 5711

Nilvadipine C19H19N3O6 [75530-68-6]

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Chemical Name: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester

Biological Activity

Syk inhibitor. Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive.

Technical Data

M.Wt:
385.37
Formula:
C19H19N3O6
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
75530-68-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Paris et al (2014) The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J.Biol.Chem. 289 33927. PMID: 25331948.

Cho et al (1989) Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J.Med.Chem. 32 2399. PMID: 2552119.

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Keywords: Nilvadipine, supplier, syk, inhibitors, inhibits, amyloid, beta, AB, Abeta, spleen, tyrosine, kinases, Alzheimer, disease, APP, amyloid, precursor, protein, L-type, calcium, channel, blockers, Ca2+, β, Tocris Bioscience, Syk Kinase Inhibitor products

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