NFAT inhibitor, Cell Permeable

Cat. No. 5710

NFAT inhibitor, Cell Permeable Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

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Alternative Name: 11R-VIVIT

Biological Activity

NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.

Technical Data

M.Wt:
3573.15
Formula:
C147H259N67O36S
Sequence:
RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
592517-80-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172. PMID: 22479554.

Noguchi et al (2004) A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat.Med. 10 305. PMID: 14770176.

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Keywords: NFAT inhibitor, Cell Permeable, supplier, NFAT, inhibitors, inhibits, nuclear, factor, of, activated, T, cells, interleukin, IL-12, IL-23, TNF, anti-inflammatory, inflammation, colitis, 11R-VIVIT, Tocris Bioscience, NFAT Inhibitor products

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