Cat. No. 5707
Chemical Name: (3S)-1-[4-[[(2,3,5,6-Tetramethylphe
Biological ActivityNrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Winkel et al (2015) Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 290 28446. PMID: 26459563.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses RA 839 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: RA 839, supplier, RA839, Nrf2, activators, activates, NFE2L2, erythroid-derived, nuclear, factors, Keap1, interations, inhibitors, inhibits, inducible, nitric, oxide, synthases, nitric, oxides, anti-inflammatory, Tocris Bioscience, Nrf2 Activator products
Find multiple products by catalog number
New Products in this Area
Gene switch ligand for use in induceable gene expression systemsML 334
Inhibitor of Keap1- Nrf2 interaction
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.