IP7e

Cat. No. 5699

IP7e C23H22N2O4 [500164-74-9]

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Chemical Name: 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one

Biological Activity

Potent Nurr1 activator (EC50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.

Technical Data

M.Wt:
390.43
Formula:
C23H22N2O4
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
500164-74-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Montarolo et al (2014) Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9 e108791. PMID: 25265488.

Hintermann et al (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 17 193. PMID: 17035009.

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Keywords: IP7e, supplier, potent, Nurr1, activators, activates, orally, bioavailable, multiple, sclerosis, MS, EAE, experimental, autoimmune, encephalomyelitis, brain, penetrant, NF-KB, κ, signaling, isoxazolo-pyridinone, 7e, Tocris Bioscience, Other Nuclear Receptor Activator products

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