Cat. No. 5699
Chemical Name: 6-[4-[(2-Methoxyethoxy)methyl]pheny
Biological ActivityPotent Nurr1 activator (EC50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Montarolo et al (2014) Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9 e108791. PMID: 25265488.
Hintermann et al (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 17 193. PMID: 17035009.
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Keywords: IP7e, supplier, potent, Nurr1, activators, activates, orally, bioavailable, multiple, sclerosis, MS, EAE, experimental, autoimmune, encephalomyelitis, brain, penetrant, NF-KB, κ, signaling, isoxazolo-pyridinone, 7e, Tocris Bioscience, Other Nuclear Receptor Activator products
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December 13 - 15, 2016