1-Methyl-D-tryptophan

Cat. No. 5698

1-Methyl-D-tryptophan C12H14N2O2 [110117-83-4]

Price and Availability

For 1-Methyl-D-tryptophan pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: 1MT

Biological Activity

Indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Technical Data

M.Wt:
218.25
Formula:
C12H14N2O2
Solubility:
Soluble to 5 mM in water with gentle warming
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
110117-83-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Nakamura et al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327. PMID: 26243621.

Rytelewski et al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439. PMID: 24587363.

If you know of a relevant reference for 1-Methyl-D-tryptophan please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses 1-Methyl-D-tryptophan from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: 1-Methyl-D-tryptophan, supplier, 1, MT, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, Tocris Bioscience, Indoleamine 2,3 dioxygenase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Alzheimer's Life Science Poster

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

divider line

Cancer Metabolism Life Science Poster

Taken from the Cancer Product Guide Edition 3

Cancer Metabolism Life Science Poster

Our Cancer Metabolism poster summarizes the main metabolic pathways in cancer cells, and highlights potential targets for cancer therapeutics. Request copy or view PDF today.

divider line

Cardiovascular Life Science Poster

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy or view PDF today.

divider line

Huntington's Disease Life Science Poster

Huntington's Disease Life Science Poster

Our Huntington's Disease (HD) poster summarizes the medium spiny neuron intracellular signaling pathways implicated in the pathology of HD. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.