Cat. No. 5698
Alternative Name: 1MT
Biological ActivityIndoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nakamura et al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327. PMID: 26243621.
Rytelewski et al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439. PMID: 24587363.
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Keywords: 1-Methyl-D-tryptophan, supplier, 1, MT, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, Tocris Bioscience, Other Oxygenase/Oxidase Inhibitor products