Cat. No. 5695
Chemical Name: 5,6,7,8-Tetrahydro-3-(2-methyl-2-pr
Biological ActivityPotent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Williams et al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43. PMID: 25818300.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Eggmanone from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Eggmanone, supplier, Potent, selective, phosphodiesterases, PDE, 4, inhibitors, inhibits, hedgehog, signallling, Tocris Bioscience, Phosphodiesterase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent PDE9 inhibitor; brain penetrantAdaptaquin
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
April 10 - 13, 2017