GSK 2033

Cat. No. 5694

GSK 2033 C29H28F3NO5S [1221277-90-2]

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Chemical Name: 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide

Biological Activity

Potent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.

Technical Data

M.Wt:
591.66
Formula:
C29H28F3NO5S
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1221277-90-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Solt et al (2012) LXR-mediated inhibition of CD4+ T helper cells. PLoS ONE 7 e46615. PMID: 23029557.

Zuercher et al (2010) Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem. 53 3412. PMID: 20345102.

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Keywords: GSK 2033, supplier, GSK2033, Potent, LXR, antagonists, liver, x, receptors, Tocris Bioscience, LXR-like Receptor Antagonist products

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