ITH 12575

Cat. No. 5692new

ITH 12575 C18H18ClNOS [1802013-08-6]

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Chemical Name: 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one

Biological Activity

Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. Reduces Ca2+ efflux from the mitochondria to the cytosol in HeLa cells (EC50 = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.

Technical Data

M.Wt:
331.86
Formula:
C18H18ClNOS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
1802013-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Martínez-Sanz et al (2015) Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration. ACS Chem.Neurosci. 6 1626. PMID: 26192029.

Moreno-Ortega et al (2015) Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology 95 503. PMID: 25908402.

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Citations are publications that use Tocris products.

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Keywords: ITH 12575, supplier, ITH12575, sodium, calcium, exchangers, inhibitors, inhibits, Na+, Ca2+, exchange, neuroprotectant, neuroprotection, mitochondrial, mNCX, Tocris Bioscience, Na+/Ca2+ Exchanger Inhibitor products

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