Cat. No. 5692
Chemical Name: 7-Chloro-1,5-dihydro-5-[2-(1-methyl
Biological ActivityMitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. Reduces Ca2+ efflux from the mitochondria to the cytosol in HeLa cells (EC50 = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Martínez-Sanz et al (2015) Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration. ACS Chem.Neurosci. 6 1626. PMID: 26192029.
Moreno-Ortega et al (2015) Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology 95 503. PMID: 25908402.
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Keywords: ITH 12575, supplier, ITH12575, sodium, calcium, exchangers, inhibitors, inhibits, Na+, Ca2+, exchange, neuroprotectant, neuroprotection, mitochondrial, mNCX, Tocris Bioscience, Na+/Ca2+ Exchanger Inhibitor products
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Potent Na+/Ca2+ exchanger (NCX) inhibitor.
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