Cat. No. 5690
Alternative Name: LCR 323
Chemical Name: 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrop
Biological ActivityHigh affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.
Licensing InformationSold with the permission of the Ludwig Institute for Cancer Research Ltd
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Wong et al (2015) Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 348 1155. PMID: 25931445.
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Keywords: Centrinone B, supplier, LCR323, high, affinity, selective, PLK4, inhibitors, inhibits, centriole, centrosome, Tocris Bioscience, Polo-like Kinase Inhibitor products
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