Centrinone

Cat. No. 5687

Centrinone C26H25F2N7O6S2 [1798871-30-3]

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Chemical Name: 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine

Biological Activity

High affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

Licensing Information

Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Technical Data

M.Wt:
633.65
Formula:
C26H25F2N7O6S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1798871-30-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wong et al (2015) Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 348 1155. PMID: 25931445.

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Keywords: Centrinone, supplier, High, affinity, selective, PLK4, inhibitors, inhibits, centriole, centrosome, Tocris Bioscience, Polo-like Kinase Inhibitor products

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