Cat. No. 5683
Chemical Name: N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)
Biological ActivityPotent, synthetic, cytotoxic analog of dolastatin 10 (Cat. No. 3375). Suppresses tumor cell viability in vitro (GIC50 values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). MMAE derivatives have been shown to induce regression of established tumor xenografts when conjugated to tumor targeting antibodies via a protease-cleavable linker.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Maderna et al (2014) Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J.Med.Chem. 57 10527. PMID: 25431858.
Doronina et al (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat.Biotechnol. 21 778. PMID: 12778055.
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Keywords: MMAE, supplier, monomethylauristatin, E, Potent, cytotoxic, dolastatin, 10, analogues, anticancer, antitumour, antitumor, tubulin, polymerization, agents, Tocris Bioscience, Microtubule products