Cat. No. 5681
Chemical Name: 4-Methoxy-N-[5-(4-methoxyphenyl)-1,
Biological ActivityActivator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kho et al (2015) Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun. 6 7229. PMID: 26068603.
If you know of a relevant reference for N106 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses N106 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: N106, supplier, SUMO-activating, enzymes, E1, ligases, SERCA2a, SUMOylation, heart, diseases, activators, Tocris Bioscience, Other Ligase Activator products
Find multiple products by catalog number
New Products in this Area
Cereblon ubiquitination inhibitor; also TNFα inhibitor and antiangiogenicLenalidomide
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligasecis VH 298
Negative control for VH 298VH 298
High-affinity inhibitor of VHLcis MZ 1
Negative Control for MZ1MZ 1
(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.