N106

Cat. No. 5681

N106 C17H14N4O3S [862974-25-2]

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Chemical Name: 4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine

Biological Activity

Activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.

Technical Data

M.Wt:
354.38
Formula:
C17H14N4O3S
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
862974-25-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Kho et al (2015) Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun. 6 7229. PMID: 26068603.

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Keywords: N106, supplier, SUMO-activating, enzymes, E1, ligases, SERCA2a, SUMOylation, heart, diseases, activators, Tocris Bioscience, Other Ligase Activator products

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