Cat. No. 5679

N-Acetylpuromycin C24H31N7O6 [22852-13-7]

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Chemical Name: 3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine

Biological Activity

Downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hernández-Damián et al (2013) Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals. Biochim.Biophys.Acta. 1830 5049. PMID: 23872350.

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Keywords: N-Acetylpuromycin, supplier, SnoN, SKI, proteins, downregulates, downregulation, transforming, growth, factor, beta, TGF-beta, TGF-B, TGF-β, signaling, ribosomes, Tocris Bioscience, TGF-β Receptor products

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