RN 9893 hydrochloride

Cat. No. 5678

RN 9893 hydrochloride C21H23F3N4O5S.HCl [1803003-68-0]

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Chemical Name: N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride

Biological Activity

Potent and selective TRPV4 antagonist (IC50 values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.

Technical Data

M.Wt:
536.95
Formula:
C21H23F3N4O5S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1803003-68-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wei et al (2015) Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg.Med.Chem.Lett. 25 4011. PMID: 26235950.

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Keywords: RN 9893 hydrochloride, supplier, RN9893, hydrochloride, potent, selective, TRPV4, transient, receptors, potential, channels, orally, bioavailable, 1803003-68-0, Tocris Bioscience, TRPV Antagonist products

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